ReFissa can be used to diminish fine facial wrinkles, fade irregular pigmentation due to sun damage, and to smooth your skin's texture and make it softer to the touch. ReFissa is different because it's available by prescription only. Also, it's clinically proven to be effective and with the FDA approval it's the only 0.05%-strong prescription tretinoin cream that's fragrance-free with a moisturizing, emollient base. ReFissa works deep at the skin's cellular level and increases collagen. As ReFissa begins to work, it may produce redness, flaking and irritation in some patients. Many people find that the signs of irritation end after a couple of months. If your skin becomes too irritated we may suggest you try using it every other night until the irritation has stopped.